dr Marzena Cydzik
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EDUCATION:
2001 – 2006 undergraduate studies at Univeristy of Silesia in Katowice, Faculty of Mathematics, Physics and Chemistry, specialization: General Chemistry, graduated with MSc in Chemistry
title of master thesis: „Synthesis of dimeric analogs of the peptide fragments of MHC class II molecules”, supervisor: Prof. Zbigniew Szewczuk
2006-2011 graduate studiesat the University of Wroclaw, Faculty of Chemistry, PhD studies completed in Chemistry and Stereochemistry of Peptide and Proteins research group, graduated with PhD in Chemistry, specialization: Organic Chemistry
title of PhD thesis: “Peptide conjugates withpoly(ethylene glycol) and quaternary ammonium salts”, supervisor: Prof. Zbigniew Szewczu
date of public defense: March 17th, 2011
2011-present postdoctoral fellow in Sunnybrook Health Sciences Centre, Toronto, Canada
Subject: anti-angiogenic peptides
Supervisor: Prof. Jean Gariepy
LIST OF PUBLICATIONS:
1. Monika Biernat, Piotr Stefanowicz, Alicja Kluczyk, Hubert Bartosz-Bechowski, Marek Cebrat, Marzena Cydzik, Michał Zimecki, Zbigniew Szewczuk
N-terminal dimerization of biologically active peptides on solid support
Peptides 2006 Prooceedings of the 29th European Peptide Symposium Gdańsk, 636-637, red. Rolka K, Rekowski P, Silberring J, Kenes International © 2007
2. Paweł Pasikowski, Marzena Cydzik, Alicja Kluczyk, Piotr Stefanowicz, Zbigniew Szewczuk
Ubiquitin fragments: their known biological activities and putative roles
BioMolecular Concepts 2010; 1: 67-83
3. Anna Łęgowska, Adam Lesner, Elżbieta Bulak, Anna Jaśkiewicz, Adam Sieradzan, Marzena Cydzik, Piotr Stefanowicz, Zbigniew Szewczuk, Krzysztof Rolka
Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing
FEBS Journal 2010; 227: 2351-2359
4. Marzena Cydzik, Magdalena Rudowska, Piotr Stefanowicz, Zbigniew Szewczuk
Derivatization of peptides as quaternary ammonium salts for sensitive detection by electrospray ionization tandem mass spectrometry
Journal of Peptide Science, 2011, 17: 445-453
5. Marzena Cydzik, Monika Biernat, Alicja Kluczyk, Piotr Stefanowicz, Remigiusz Bąchor, Michał Zimecki, Zbigniew Szewczuk
Dimerization of the immunosuppressory decapeptide ubiquitin fragment
Peptides 2010 Prooceedings of the 31th European Peptide Symposium Kopenhaga, 96-97, red. Lebl M, Meldal M, Jensen KJ, Hoeg-Jensen T, 2010
6. Marzena Cydzik, Magdalena Rudowska, Piotr Stefanowicz, Zbigniew Szewczuk
The competition of charge remote and charge directed fragmentation mechanisms in quaternary ammonium salt derivatized peptides-an isotopic exchange study
Journal of the American Society for Mass Spectrometry, 2011 Oct 5 [Epub ahead of print]
CONFERENCES:
1. Cyclodimerization of immunosuppressive peptide fragment of HLA-DR molecule
Marzena Cydzik, Monika Biernat, Michał Zimecki, Piotr Stefanowicz, Alicja Kluczyk, Zbigniew Szewczuk
2nd European Conference on Chemistry for Life Sciences, 4-8 IX 2007, Wroclaw, Poland
poster presentation
2. Design and synthesis of a cyclodimeric analog of the nonapeptide immunosuppressive HLA-DR fragment
Marzena Cydzik, Monika Biernat, Piotr Stefanowicz, Alicja Kluczyk, Michał Zimecki, Zbigniew Szewczuk
19 Polish Peptide Symposium, 23-27 IX 2007, Pultusk, Poland
oral communication presented in English (20min)
3. Cyclodimerization of immunosuppressive peptide fragment of HLA-DR molecule
Marzena Cydzik, Monika Biernat, Michał Zimecki, Piotr Stefanowicz, Alicja Kluczyk, Zbigniew Szewczuk
19 Polish Peptide Symposium, 23-27 IX 2007, Pultusk, Poland
poster presentation
4. Fragmentation of the cyclodimeric analog of immunosuppressive HLA-DR fragment
Marzena Cydzik, Monika Biernat, Piotr Stefanowicz, Alicja Kluczyk, Zbigniew Szewczuk
1 Conference of Polish Mass Spectrometry Society, 16-18 IV 2008, Pulawy, Polska
oral communication presented in English (20min)
5. Effect of sodium cations on the conformational preferences of peptides bridged by PEG linkers
Marzena Cydzik, Paweł Pasikowski, Alicja Kluczyk, Monika Biernat, Marek Lisowski, Zbigniew Szewczuk
9th European Biological Inorganic Chemistry Conference, 2-6 IX 2008, Wroclaw, Poland
poster presentation
6. Dimerization of the immunosuppressory decapeptide fragmnet of ubiquitin - synthesis and immunomodulatory activity
Marzena Cydzik, Monika Biernat, Alicja Kluczyk, Piotr Stefanowicz, Remigiusz Bąchor, Michał Zimecki, Zbigniew Szewczuk
20 Polish Peptide Symposium, 6-10 IX 2009, Wladyslawowo, Poland
poster presentation
7. A Model of Charge-remote peptide fragmentation. Synthesis and CID-MS analysis of peptides containing quaternary ammonium salts
Marzena Cydzik, Magdalena Rudowska, Piotr Stefanowicz, Zbigniew Szewczuk
2nd Conference of Polish Mass Spectrometry Society, 24-26 III 2010, Poznan, Poland
poster presentation
8. N-terminal dimerization of biologically active peptides on solid support
Zbigniew Szewczuk, Monika Biernat, Piotr Stefanowicz, Hubert Bartosz-Bechowski, Marek Cebrat, Alicja Kluczyk, Marzena Cydzik, Michał Zimecki, Marcin Paduch, Jacek Otlewski
29th European Peptide Symposium, 3-8 IX 2006, Gdansk, Poland
9. The power of two - dimeric analogs of the immunosuppressory fragment of HLA-DR molecules
Monika Biernat, Marzena Cydzik, Piotr Stefanowicz, Alicja Kluczyk, Michał Zimecki, Zbigniew Szewczuk
2nd European Conference on Chemistry for Life Sciences, 4-8 IX 2007, Wroclaw, Poland
10. New peptide derivatization for enhancing ioionization
Magdalena Rudowska, Alicja Kluczyk, Piotr Stefanowicz, Marzena Cydzik, Zbigniew Szewczuk
2nd Conference of Polish Mass Spectrometry Society, 24-26 III 2010, Poznan, Poland
11. Dimerization of the immunosuppressory decapeptide ubiquitin fragment
Marzena Cydzik, Monika Biernat, Alicja Kluczyk, Piotr Stefanowicz, Remigiusz Bąchor, Michał Zimecki, Zbigniew Szewczuk
31th European Peptide Symposium, 5-9 IX 2010, Kopenhaga, Denmark
